Well I mostly went for Renegade because those were the answers that appealed to me. Dont worry about having to go full renegade or paragon though, the reputation system works differently from ME2. You dont need to go renegade to unlock more renegade conversation options, ME3 combines your paragon and renegade scores into a "reputation" (which you can see on your squad menu). Depending on that combined score options may unlock.
Finished ME3 last night though. Kind of surprised about it. It took me like 35 hours now because I needed to figure everything out, explored a lot, talked to a lot of characters multiple times hoping to get new conversations etc. Knowing fully how the game works I could probably do it again in less than half that.
Artist formerly known as "Dev"